Cytokine-regulated expression of activated leukocyte cell adhesion molecule (CD166) on monocyte-lineage cells and in rheumatoid arthritis synovium
نویسندگان
چکیده
منابع مشابه
Junctional adhesion molecule C mediates leukocyte adhesion to rheumatoid arthritis synovium.
OBJECTIVE Leukocyte infiltration into the rheumatoid arthritis (RA) synovium is a multistep process in which leukocytes leave the bloodstream and invade the synovial tissue (ST). Leukocyte transendothelial migration and adhesion to RA ST requires adhesion molecules on the surface of endothelial cells and RA ST fibroblasts. This study was undertaken to investigate the role of junctional adhesion...
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Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166), is expressed on osteoblasts (OB) and hematopoietic stem cells (HSC) residing in the hematopoietic niche, and may have important regulatory roles in bone formation. Because HSC numbers are reduced 77% in CD166(-/-) mice, we hypothesized that changes in bone phenotype and consequently the endosteal niche may partially be responsible for th...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1998
ISSN: 0004-3591,1529-0131
DOI: 10.1002/1529-0131(199812)41:12<2221::aid-art18>3.0.co;2-i